Norrin antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX85292
Zusätzliche Namen:: norrin cystine knot growth factor NDP , EVR2 , FEVR , ND
Anwendung:: ELISA, WB, IF, ICC
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: PBS, 0.02% Sodium azide.
Immunogen:: Norrin antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human Norrin.The immunogen is located within the first 50 amino acids of Norrin.
Uniprot:: Q00604
Synonyme:: EVR2;FEVR;ND;NDP, norrin cystine knot growth factor;Norrie disease (pseudoglioma);norrie disease protein;norrin;X-linked exudative vitreoretinopathy 2 protein
Weitere Details:: Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/b-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina; transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/b-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.

Versandbedingungen:: Blue Ice