GTX85283
ST3gal6 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85283
- Zusätzliche Namen:
- ST3 beta-galactoside alpha-2,3-sialyltransferase 6 , SIAT10 , ST3GALVI
- Anwendung:
- ELISA, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- ST3gal6 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ST3gal6.The immunogen is located within amino acids 230 - 280 of ST3gal6.
- Uniprot:
- Q9Y274
- Synonyme:
- alpha2,3-sialyltransferase ST3Gal VI;CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI;Sialyltransferase 10;sialyltransferase 10 (alpha-2,3-sialyltransferase VI);SIAT10;ST3Gal VI;ST3GALVI;type 2 lactosamine alpha-2,3-sialyltransferase
- Weitere Details:
- Sialyltransferases catalyze the transfer of sialic acid from cytidine 5-prime monophospho-N-acetylneuraminic acid (CMP-NeuAc) to terminal positions of glycoprotein and glycolipid carbohydrate groups. Terminal NeuAc residues are key determinants of carbohydrate structures, such as the sialyl-Lewis X determinants, and are widely distributed in many cell types. However, cancer cells often express more heavily sialylated glycans on their cell surface and this feature sometimes correlates with invasiveness. In contrast, expression of ST3gal6, a member of the sialyltransferase family that sialylates type II lactosamine structures on glycoproteins and glycolipids, was found to be significantly decreased by hypermethylation of the gene in gastrointestinal cancer. At least three isoforms of ST3gal6 are known to exist.
- Versandbedingungen:
- Blue Ice