GTX85282
RSPO1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85282
- Zusätzliche Namen:
- R-spondin 1 , CRISTIN3 , RSPO
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- RSPO1 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human RSPO1.The immunogen is located within the first 50 amino acids of RSPO1.
- Uniprot:
- Q2MKA7
- Synonyme:
- CRISTIN3;R-spondin homolog;R-spondin-1;roof plate-specific spondin-1;RSPO
- Weitere Details:
- RSPO1 is a member of a family of secreted growth factors that can operate through the canonical Wnt signaling pathway by stabilizing the intracellular b-catenin, thereby regulating functions mediated by b-catenin such as cell fate decisions and embryonic patterning. RSPO1 was recently identified through linkage analysis to be involved in sex determination and mammalian ovarian development. RSPO1 is thought to regulate cellular responsiveness to Wnt ligands by modulating the cell-surface expression of the Wnt co-receptor LRP6 by interfering with the DKK/Kremen-mediated internalization of LRP6 through an interaction with Kremen, resulting in increased LRP6 cell-surface levels. At least two isoforms of RSPO1 are known to exist. RSPO1 antibody will not cross-react with RSPO family members.
- Versandbedingungen:
- Blue Ice