SHOC2 antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX85278
Zusätzliche Namen:: SHOC2 leucine rich repeat scaffold protein , SIAA0862 , SOC2 , SUR8
Anwendung:: ELISA, WB, IHC-P
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: PBS, 0.02% Sodium azide.
Immunogen:: SHOC2 antibody was raised against a 21 amino acid synthetic peptide near the amino terminus of human SHOC2.The immunogen is located within amino acids 30 - 80 of SHOC2.
Uniprot:: Q9UQ13
Synonyme:: leucine-rich repeat protein SHOC-2;NSLH1;Protein soc-2 homolog;Protein sur-8 homolog;SIAA0862;soc-2 suppressor of clear homolog;SOC2;SUR8
Weitere Details:: SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.

Versandbedingungen:: Blue Ice