GTX85266
STING antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85266
- Zusätzliche Namen:
- transmembrane protein 173 , ERIS , MITA , MPYS , NET23 , SAVI , STING , STING-beta , hMITA , hSTING
- Anwendung:
- ELISA, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- MPYS antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human MPYS.The immunogen is located within amino acids 260 - 310 of MPYS.
- Uniprot:
- Q86WV6
- Synonyme:
- endoplasmic reticulum IFN stimulator;endoplasmic reticulum interferon stimulator;ERIS;hMITA;hSTING;Mediator of IRF3 activation;MITA;mitochondrial mediator of IRF3 activation;MPYS;N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner;NET23;SAVI;stimulator of interferon genes protein;stimulator of interferon protein;STING;STING-beta;TMEM173;transmembrane protein 173
- Weitere Details:
- MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.
- Versandbedingungen:
- Blue Ice