GTX85253
KDM3A antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85253
- Zusätzliche Namen:
- lysine demethylase 3A , JHDM2A , JHMD2A , JMJD1 , JMJD1A , TSGA
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- KDM3A antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human KDM3A.The immunogen is located within amino acids 50 - 100 of KDM3A.
- Uniprot:
- Q9Y4C1
- Synonyme:
- [histone H3]-dimethyl-L-lysine(9) demethylase 3A;JHDM2A;JHMD2A;jmjC domain-containing histone demethylation protein 2A;JMJD1;JMJD1A;jumonji C domain-containing histone demethylase 2A;jumonji domain-containing protein 1A;lysine (K)-specific demethylase 3A;lysine-specific demethylase 3A;testis-specific protein A;TSGA
- Weitere Details:
- The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. JMJD1A is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of STAT3, a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells, and decreased JMJD1A expression correlated with the differentiation of cultured mES cells following the removal of the cytokine LIF. These findings suggest that JMJD1A might be a critical signaling molecule underlying the maintenance of pluripotency in embryonic stem cells. At least two isoforms of JMJD1A are known to exist. This antibody will not cross-react with JMJD1B or JMJD1C.
- Versandbedingungen:
- Blue Ice