SKA2 antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX85247
Zusätzliche Namen:: spindle and kinetochore associated complex subunit 2 , FAM33A
Anwendung:: ELISA, WB
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: PBS, 0.02% Sodium azide.
Immunogen:: SKA2 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human SKA2.The immunogen is located within the first 50 amino acids of SKA2.
Uniprot:: Q8WVK7
Synonyme:: FAM33A;family with sequence similarity 33, member A;Protein FAM33A;spindle and kinetochore-associated protein 2;spindle and KT (kinetochore) associated 2
Weitere Details:: Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing. SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation.

Versandbedingungen:: Blue Ice