GTX85243
INSM1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85243
- Zusätzliche Namen:
- INSM transcriptional repressor 1 , IA-1 , IA1
- Anwendung:
- ELISA, WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- IA-1 antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human IA-1.The immunogen is located within amino acids 90 - 140 of IA-1.
- Uniprot:
- Q01101
- Synonyme:
- IA-1;IA1;insulinoma-associated 1;insulinoma-associated protein 1;zinc finger protein IA-1
- Weitere Details:
- IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
- Versandbedingungen:
- Blue Ice