GTX85240
CKIP1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85240
- Zusätzliche Namen:
- pleckstrin homology domain containing O1 , CKIP-1 , CKIP1 , JBP , OC120
- Anwendung:
- ELISA, WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- CKIP1 antibody was raised against an 18 amino acid synthetic peptide from near the carboxy terminus of human CKIP1.The immunogen is located within the last 50 amino acids of CKIP1.
- Uniprot:
- Q53GL0
- Synonyme:
- C-Jun-binding protein;casein kinase 2-interacting protein 1;CK2 interacting protein 1; HQ0024c protein;CK2-interacting protein 1;CKIP-1;CKIP1;JBP;OC120;osteoclast maturation-associated gene 120 protein;PH domain-containing family O member 1;pleckstrin homology domain-containing family O member 1
- Weitere Details:
- CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha', and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.
- Versandbedingungen:
- Blue Ice