GTX85237
Mimitin antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85237
- Zusätzliche Namen:
- NADH:ubiquinone oxidoreductase complex assembly factor 2 , B17.2L , MC1DN10 , MMTN , NDUFA12L , mimitin
- Anwendung:
- ELISA, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- Mimitin antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Mimitin.The immunogen is located within the last 50 amino acids of Mimitin.
- Uniprot:
- Q8N183
- Synonyme:
- B17.2-like;B17.2L;MC1DN10;mimitin;mimitin, mitochondrial;MMTN;Myc-induced mitochondrial protein;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2;NADH dehydrogenase (ubiquinone) complex I, assembly factor 2;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2;NADH dehydrogenase 1 alpha subcomplex assembly factor 2;NDUFA12-like protein;NDUFA12L
- Weitere Details:
- Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kB-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.
- Versandbedingungen:
- Blue Ice