GTX85231
FAM59A antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85231
- Zusätzliche Namen:
- GRB2 associated regulator of MAPK1 subtype 1 , C18orf11 , FAM59A , GAREM , Gm944
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- FAM59A antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human FAM59A.The immunogen is located within amino acids 630 - 680 of FAM59A.
- Uniprot:
- Q9H706
- Synonyme:
- C18orf11;FAM59A;family with sequence similarity 59, member A;GAREM;Gm944;GRB2 associated regulator of MAPK1 1;GRB2 associated, regulator of MAPK1;Grb2-associated and regulator of Erk/MAPK;GRB2-associated and regulator of MAPK protein 1;GRB2-associated and regulator of MAPK1;protein FAM59A
- Weitere Details:
- FAM59A, also known as GAREM, was initially identified through a mass spectroscoptic method that measures different phosphotyrosine states of proteins in response to different cell stimuli. FAM59A is a downstream molecule in the EGF signaling pathway that is tyrosine-phosphorylated, and this phosphorylation is needed for the binding of Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. ERK activation in response to EGF stimulation is regulated by FAM59A in COS-7 and HeLa cells, and the overexpression of FAM59A stimulated cell proliferation and colony formation in soft agar, suggesting that FAM59A might be a critical protein with roles in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.
- Versandbedingungen:
- Blue Ice