GTX85207
CALHM1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85207
- Zusätzliche Namen:
- calcium homeostasis modulator 1 , FAM26C
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- CALHM1 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CALHM1.The immunogen is located within amino acids 60 - 110 of CALHM1.
- Uniprot:
- Q8IU99
- Synonyme:
- calcium homeostasis modulator protein 1;FAM26C;family with sequence similarity 26, member C;Protein FAM26C
- Weitere Details:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-b (Ab) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Ab levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.
- Versandbedingungen:
- Blue Ice