GTX85203
DCLK3 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85203
- Zusätzliche Namen:
- doublecortin like kinase 3 , CLR , DCAMKL3 , DCDC3C , DCK3
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- DCLK3 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human DCLK3.The immunogen is located within the last 50 amino acids of DCLK3.
- Uniprot:
- Q9C098
- Synonyme:
- CLICK-I,II-related;CLR;DCAMKL3;DCDC3C;DCK3;doublecortin and CaM kinase-like 3;doublecortin domain-containing protein 3C;doublecortin-like and CAM kinase-like 3;Doublecortin-like kinase 3;serine/threonine-protein kinase DCLK3
- Weitere Details:
- DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization.
- Versandbedingungen:
- Blue Ice