GTX85185
NSE2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85185
- Zusätzliche Namen:
- NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase , C8orf36 , MMS21 , NSE2 , ZMIZ7
- Anwendung:
- ELISA, WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- MMS21 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human MMS21.The immunogen is located within amino acids 170 - 220 of MMS21.
- Uniprot:
- Q96MF7
- Synonyme:
- C8orf36;E3 SUMO-protein ligase NSE2;E3 SUMO-protein transferase NSE2;methyl methanesulfonate sensitivity gene 21;MMS21;MMS21 homolog;non-SMC element 2, MMS21 homolog;non-structural maintenance of chromosomes element 2 homolog;NSE2;NSMCE2/PVT1 fusion;PVT1/NSMCE2 fusion;zinc finger, MIZ-type containing 7;ZMIZ7
- Weitere Details:
- MMS21, also known as NSE2, is a SUMO ligase that in combination with the SMC5/6 complex is required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells. MMS21-dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression; this function appears to be independent of SMC6. MMS21 mediates SUMO attachment to various proteins such as SMC6L1 and TRAX, and possibly the cohesin components RAD21 and STAG2.
- Versandbedingungen:
- Blue Ice