APBA2 antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX85144
Zusätzliche Namen:: amyloid beta precursor protein binding family A member 2 , D15S1518E , HsT16821 , LIN-10 , MGC:14091 , MINT2 , X11-BETA , X11L
Anwendung:: ELISA, WB, IHC-P
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: PBS, 0.02% Sodium azide.
Immunogen:: APBA2 antibody was raised against an 18 amino acid synthetic peptide near the center of human APBA2.The immunogen is located within amino acids 290 - 340 of APBA2.
Uniprot:: Q99767
Synonyme:: adapter protein X11beta;amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like);amyloid-beta A4 precursor protein-binding family A member 2;D15S1518E;HsT16821;LIN-10;MGC:14091;mint-2;MINT2;neuron-specific X11L protein;neuronal munc18-1-interacting protein 2;phosphotyrosine-binding/-interacting domain (PTB)-bearing protein;X11-BETA;X11-like protein;X11L
Weitere Details:: APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.

Versandbedingungen:: Blue Ice