GTX85142
EFCAB4B antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85142
- Zusätzliche Namen:
- calcium release activated channel regulator 2A , EFCAB4B
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- EFCAB4B antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human EFCAB4B.The immunogen is located within amino acids 640 - 690 of EFCAB4B.
- Uniprot:
- Q9BSW2
- Synonyme:
- Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A;calcium release-activated calcium channel regulator 2A;Calcium release-activated channel regulator 2A;CRAC channel regulator 2A;CRAC regulator 2A;EF-hand calcium binding domain 4B;EF-hand calcium-binding domain-containing protein 4B;EFCAB4B;RAB46;ras-related protein Rab-46
- Weitere Details:
- EFCAB4B, also known as Calcium release-activated calcium channel regulator 2A, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation. EFCAB4B acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. A closely related protein, EFCAB4A, is likely to play a similar role as EFCAB4B, but the detailed function of EFCAB4A is still under investigation.
- Versandbedingungen:
- Blue Ice