GTX85135
ZIP1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85135
- Zusätzliche Namen:
- solute carrier family 39 member 1 , ZIP1 , ZIRTL
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- ZIP1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human ZIP1.The immunogen is located within amino acids 40 - 90 of ZIP1.
- Uniprot:
- Q9NY26
- Synonyme:
- solute carrier family 39 (zinc transporter), member 1;solute carrier family 39 (zinc transporter), member 3;Solute carrier family 39 member 1;zinc transporter ZIP1;Zinc-iron-regulated transporter-like;ZIP1;ZIRTL;zrt- and Irt-like protein 1
- Weitere Details:
- ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappaB, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.
- Versandbedingungen:
- Blue Ice