GTX85101
Raf1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85101
- Zusätzliche Namen:
- Raf-1 proto-oncogene, serine/threonine kinase , CMD1NN , CRAF , NS5 , Raf-1 , c-Raf
- Anwendung:
- ELISA, WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Chicken/Avian
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- C-raf antibody was raised against an 19 amino acid synthetic peptide near the amino terminus of human C-raf.The immunogen is located within amino acids 30 - 80 of C-raf.
- Uniprot:
- P04049
- Synonyme:
- c-Raf;C-Raf proto-oncogene, serine/threonine kinase;CMD1NN;CRAF;NS5;Oncogene RAF1;proto-oncogene c-RAF;raf proto-oncogene serine/threonine protein kinase;RAF proto-oncogene serine/threonine-protein kinase;Raf-1;v-raf-1 murine leukemia viral oncogene homolog 1;v-raf-1 murine leukemia viral oncogene-like protein 1
- Weitere Details:
- C-raf is the cellular homolog of viral raf gene (v-raf) and encodes a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases. Once activated, C-raf phosphorylates and activates the protein kinases MEK1 and MEK2, which in turn phosphorylate and activate the serine/threonine specific protein kinases, ERK1 and ERK2. These activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
- Versandbedingungen:
- Blue Ice