GTX85084
APOBEC3G antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85084
- Zusätzliche Namen:
- apolipoprotein B mRNA editing enzyme catalytic subunit 3G , A3G , ARCD , ARP-9 , ARP9 , CEM-15 , CEM15 , MDS019 , bK150C2.7 , dJ494G10.1
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- APOBEC3G antibody was raised against a synthetic peptide corresponding to 15 amino acids near the amino-terminus of human APOBEC3G.The immunogen is located within the first 50 amino acids of APOBEC3G.
- Uniprot:
- Q9HC16
- Synonyme:
- A3G;APOBEC-related cytidine deaminase;APOBEC-related protein 9;apolipoprotein B editing enzyme catalytic polypeptide-like 3G;apolipoprotein B mRNA editing enzyme cytidine deaminase;apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G;apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G;ARCD;ARP-9;ARP9;bK150C2.7;CEM-15;CEM15;deoxycytidine deaminase;dJ494G10.1;DNA dC->dU editing enzyme;DNA dC->dU-editing enzyme APOBEC-3G;MDS019;phorbolin-like protein MDS019
- Weitere Details:
- The Apoliprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates (1). Similar to TRIM5alpha which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection (2,3) as at least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated HIV-1 virions and induce hypermutation in the newly synthesized viral DNA and thus destabilize the viral genome (4,5). This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G; a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity (6).
- Versandbedingungen:
- Blue Ice