GTX85081
ECSIT antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85081
- Zusätzliche Namen:
- ECSIT signalling integrator , SITPEC
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- ECSIT antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human ECSIT.The immunogen is located within amino acids 290 - 340 of ECSIT.
- Uniprot:
- Q9BQ95
- Synonyme:
- ECSIT homolog;ECSIT signalling integrator;evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial;likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved;Protein SITPEC;SITPEC
- Weitere Details:
- Activation of NF-?B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2) to kinases such as IRAK (3) and other intermediates such as TNF receptor associated factor (TRAF)-6 (4). ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway (5). Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis (6), indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.
- Versandbedingungen:
- Blue Ice