GTX85064
PEN2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85064
- Zusätzliche Namen:
- presenilin enhancer, gamma-secretase subunit , ACNINV2 , MDS033 , MSTP064 , PEN-2 , PEN2
- Anwendung:
- ELISA, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- PEN2 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human PEN2.The immunogen is located within the last 50 amino acids of PEN2.
- Uniprot:
- Q9NZ42
- Synonyme:
- ACNINV2;gamma-secretase subunit PEN-2;hematopoietic stem/progenitor cells protein MDS033;MDS033;MSTP064;PEN-2;PEN2;presenilin enhancer 2 homolog;Presenilin enhancer protein 2
- Weitere Details:
- PEN2, in addition to presenilin, nicastrin, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic A
- Versandbedingungen:
- Blue Ice