GTX85057
Orai1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85057
- Zusätzliche Namen:
- ORAI calcium release-activated calcium modulator 1 , CRACM1 , IMD9 , ORAT1 , TAM2 , TMEM142A
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- ORAI1 antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human ORAI1.The immunogen is located within the first 50 amino acids of ORAI1.
- Uniprot:
- Q96D31
- Synonyme:
- calcium release-activated calcium channel protein 1;calcium release-activated calcium modulator 1;CRACM1;IMD9;ORAT1;protein orai-1;TAM2;TMEM142A;transmembrane protein 142A
- Weitere Details:
- Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
- Versandbedingungen:
- Blue Ice