GTX85046
NHE-1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85046
- Zusätzliche Namen:
- solute carrier family 9 member A1 , APNH , LIKNS , NHE-1 , NHE1 , PPP1R143
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- Nhe-1 antibody was raised against a 17 amino acid synthetic peptide near the center of the human Nhe-1.The immunogen is located within amino acids 490 - 540 of Nhe-1.
- Uniprot:
- P19634
- Synonyme:
- APNH;LIKNS;Na-Li countertransporter;Na(+)/H(+) antiporter, amiloride-sensitive;Na(+)/H(+) exchanger 1;NHE-1;NHE1;PPP1R143;protein phosphatase 1, regulatory subunit 143;sodium/hydrogen exchanger 1;solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive);Solute carrier family 9 member 1;solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
- Weitere Details:
- The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.
- Versandbedingungen:
- Blue Ice