GTX85045
KA1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85045
- Zusätzliche Namen:
- glutamate receptor, ionotropic, kainate 4 , 6330551K01Rik , GluK4 , GluRgamma1 , KA-1 , KA1
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human, Mouse
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- KA1 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of the mouse KA1.The immunogen is located within the last 50 amino acids of KA1.
- Uniprot:
- Q8BMF5
- Synonyme:
- 6330551K01Rik;GluK4;GluRga;GluRgamma1;glutamate receptor ionotropic, kainate 4;glutamate receptor KA1;KA;KA-;KA-1;KA1
- Weitere Details:
- Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE.
- Versandbedingungen:
- Blue Ice