GTX85034
GPAM antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85034
- Zusätzliche Namen:
- glycerol-3-phosphate acyltransferase, mitochondrial , GPAT , GPAT1
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- GPAM antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human GPAM .The immunogen is located within amino acids 730 - 780 of GPAM.
- Uniprot:
- Q9HCL2
- Synonyme:
- glycerol-3-phosphate acyltransferase 1, mitochondrial;GPAT;GPAT-1;GPAT1
- Weitere Details:
- Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.
- Versandbedingungen:
- Blue Ice