GTX85033
LIMP II antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85033
- Zusätzliche Namen:
- scavenger receptor class B member 2 , AMRF , CD36L2 , EPM4 , HLGP85 , LGP85 , LIMP-2 , LIMPII , SR-BII
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- LIMP2 antibody was raised against a 16 amino acid synthetic peptide from near the center of human LIMP2.The immunogen is located within amino acids 70 - 120 of LIMP2.
- Uniprot:
- Q14108
- Synonyme:
- 85 kDa lysosomal membrane sialoglycoprotein;85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2;AMRF;CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II);CD36 antigen-like 2;CD36L2;EPM4;HLGP85;LGP85;LIMP II;LIMP-2;LIMPII;lysosome membrane protein 2;lysosome membrane protein II;Scavenger receptor class B member 2;SR-BII
- Weitere Details:
- The lysosomal integral membrane protein 2 (LIMP2) is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP2 in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP2 was shown to act as a receptor to bind b-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP2-deficient mice showed missorted as well as secreted b-glucocerebrosidase, suggesting that LIMP2 also functions as the mannose-6-phosphate-independent trafficking receptor. Despite its predicted molecular weight, LIMP2 runs at approximately 80 - 85 kDa in SDS-PAGE.
- Versandbedingungen:
- Blue Ice