GTX85030
CLIP170 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85030
- Zusätzliche Namen:
- CAP-Gly domain containing linker protein 1 , CLIP , CLIP-170 , CLIP170 , CYLN1 , RSN
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- CLIP170 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human CLIP170.The immunogen is located within amino acids 1340 - 1390 of CLIP170.
- Uniprot:
- P30622
- Synonyme:
- CAP-Gly domain-containing linker protein 1;CLIP;CLIP-170;CLIP170;CYLN1;cytoplasmic linker protein 1;cytoplasmic linker protein 170 alpha-2;cytoplasmic linker protein CLIP-170;Reed-Sternberg intermediate filament-associated protein;Restin;restin (Reed-Steinberg cell-expressed intermediate filament-associated protein);RSN
- Weitere Details:
- CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.
- Versandbedingungen:
- Blue Ice