GTX85029
BICD1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85029
- Zusätzliche Namen:
- BICD cargo adaptor 1 , BICD , bic-D 1
- Anwendung:
- ELISA, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- BICD1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human BICD1.The immunogen is located within the last 50 amino acids of BICD1.
- Uniprot:
- Q96G01
- Synonyme:
- bic-D 1;bicaudal D homolog 1;BICD;cytoskeleton-like bicaudal D protein homolog 1;protein bicaudal D homolog 1
- Weitere Details:
- BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells. At least two isoforms of BICD1 are known to exist; this antibody will only recognize the larger isoform.
- Versandbedingungen:
- Blue Ice