GTX85013
SKA3 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85013
- Zusätzliche Namen:
- spindle and kinetochore associated complex subunit 3 , C13orf3 , RAMA1
- Anwendung:
- ELISA, WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- SKA3 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human SKA3.The immunogen is located within amino acids 290 - 340 of SKA3.
- Uniprot:
- Q8IX90
- Synonyme:
- C13orf3;RAMA1;spindle and kinetochore-associated protein 3
- Weitere Details:
- Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Like with SKA1 or SKA2, depletion of SKA3 by siRNA delays anaphase transition, resulting in a prolonged a metaphase-like state. These SKA3-depleted cells accumulate high levels of the checkpoint protein Bub1 at kinetochores, suggesting the SKA complex plays a key role in spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis.
- Versandbedingungen:
- Blue Ice