GTX85010
BFAR antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85010
- Zusätzliche Namen:
- bifunctional apoptosis regulator , BAR , RNF47
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- BFAR antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human BFAR.The immunogen is located within amino acids 300 - 350 of BFAR.
- Uniprot:
- Q9NZS9
- Synonyme:
- BAR;bifunctional apoptosis inhibitor;bifunctional apoptosis regulator;RING finger protein 47;RNF47
- Weitere Details:
- The bifunctional apoptosis inhibitor (BFAR) is scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors ('extrinsic pathway') as well as mitochondria-dependent apoptosis ('intrinsic pathway'). Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain may contribute to the anti-apoptotic properties of BFAR. In addition, BFAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. BFAR is also thought to be involved in the regulation of neuronal survival.
- Versandbedingungen:
- Blue Ice