GTX85005
ATG3 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85005
- Zusätzliche Namen:
- autophagy related 3 , APG3 , APG3-LIKE , APG3L , PC3-96
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- ATG3 antibody was raised against an 18 amino acid synthetic peptide near the center of human ATG3.The immunogen is located within amino acids 180 - 230 of ATG3.
- Uniprot:
- Q9NT62
- Synonyme:
- 2610016C12Rik;APG3;APG3 autophagy 3-like;APG3-LIKE;APG3L;ATG3 autophagy related 3 homolog;autophagy-related protein 3;hApg3;PC3-96;Protein PC3-96;ubiquitin-like-conjugating enzyme ATG3
- Weitere Details:
- Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. It functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.
- Versandbedingungen:
- Blue Ice