Chk2 antibody [5C4]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX84691
Zusätzliche Namen:: checkpoint kinase 2 , CDS1 , CHK2 , HuCds1 , LFS2 , PP1425 , RAD53 , hCds1
Anwendung:: Flow Cytometry, WB, IHC-P, IF, ICC, IP
Konzentration:: 1.43 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Canine, Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full length human recombinant protein of human CHEK2 (NP_009125) produced in HEK293T cell.
Klon:: 5C4
Uniprot:: O96017
Synonyme:: CDS1;cds1 homolog;Checkpoint kinase 2;checkpoint-like protein CHK2;CHK2;CHK2 checkpoint homolog;hCds1;HuCds1;LFS2;PP1425;RAD53;serine/threonine-protein kinase Chk2
Weitere Details:: Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.