HIPPI antibody [4F6]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX84310
Zusätzliche Namen:: intraflagellar transport 57 , ESRRBL1 , HIPPI , MHS4R2 , OFD18
Anwendung:: WB, IHC-P, IF, ICC
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human, Mouse, Rat
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full length human recombinant protein of human IFT57(NP_060480) produced in HEK293T cell.
Klon:: 4F6
Uniprot:: Q9NWB7
Synonyme:: dermal papilla-derived protein 8;ESRRBL1;estrogen-related receptor beta like 1;estrogen-related receptor beta-like protein 1;HIP1 protein interactor;HIP1-interacting protein;HIPPI;huntingtin interacting protein-1 interacting protein;intraflagellar transport 57 homolog;intraflagellar transport protein 57 homolog;MHS4R2;OFD18
Weitere Details:: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator | however the relevance of such function remains unclear.

Versandbedingungen:: Blue Ice