JNK1 antibody [4E3]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX84144
Zusätzliche Namen:: mitogen-activated protein kinase 8 , JNK , JNK-46 , JNK1 , JNK1A2 , JNK21B1/2 , PRKM8 , SAPK1 , SAPK1c
Anwendung:: WB, IHC-P, IF, ICC
Konzentration:: 0.66 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Human recombinant protein fragment corresponding to amino acids 1-384 of human JNK1 (NP_002741) produced in E.coli.
Klon:: 4E3
Uniprot:: P45983
Synonyme:: c-Jun N-terminal kinase 1;JNK;JNK-46;JNK1;JNK1A2;JNK21B1/2;JUN N-terminal kinase;MAP kinase 8;mitogen-activated protein kinase 8;PRKM8;SAPK1;SAPK1c;stress-activated protein kinase 1;stress-activated protein kinase 1c;Stress-activated protein kinase JNK1
Weitere Details:: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Versandbedingungen:: Blue Ice