PIM2 antibody [10A12]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX83886
Zusätzliche Namen:: Pim-2 proto-oncogene, serine/threonine kinase
Anwendung:: Flow Cytometry, WB, IHC-P
Konzentration:: 0.84 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Canine, Human, Rat
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full length human recombinant protein of human PIM2 (NP_006866) produced in HEK293T cell.
Klon:: 10A12
Uniprot:: Q9P1W9
Synonyme:: pim-2 oncogene;pim-2h;proto-oncogene Pim-2 (serine threonine kinase);serine/threonine-protein kinase pim-2
Weitere Details:: Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappaB kinase/NF-kappaB cascade | this process requires phosphorylation of MAP3K8/COT. Prevents apoptosis induced by growth factor withdrawal via inhibition of caspase-3 activation, and via phosphorylation of pro-apoptotic proteins. Inhibits BAD-induced cell death via phosphorylation of BAD. PIM2-mediated cell survival is glucose-dependent but independent of several AKT regulators such as PI3K, HSP-90 and TOR, indicating that PIM2 and PI3K/AKT/TOR function via distinct pathways. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

Versandbedingungen:: Blue Ice