PLK1 antibody [1D4]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX83865
Zusätzliche Namen:: polo like kinase 1 , PLK , STPK13
Anwendung:: Flow Cytometry, WB, IHC-P, IP
Konzentration:: 2.5 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full length human recombinant protein of human PLK1 (NP_005021) produced in HEK293T cell.
Klon:: 1D4
Uniprot:: P53350
Synonyme:: cell cycle regulated protein kinase;PLK;PLK-1;polo (Drosophia)-like kinase;Polo-like kinase 1;serine/threonine-protein kinase 13;serine/threonine-protein kinase PLK1;STPK13
Weitere Details:: Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.

Versandbedingungen:: Blue Ice