PTPRE antibody [4B2]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX83763
Zusätzliche Namen:: protein tyrosine phosphatase receptor type E , HPTPE , PTPE , R-PTP-EPSILON
Anwendung:: Flow Cytometry, WB, IHC-P, IF, ICC
Konzentration:: 0.89 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full length human recombinant protein of human PTPRE (NP_006495) produced in HEK293T cell.
Klon:: 4B2
Uniprot:: P23469
Synonyme:: HPTPE;protein tyrosine phosphatase, receptor type, epsilon polypeptide;PTPE;R-PTP-EPSILON;receptor-type tyrosine-protein phosphatase epsilon
Weitere Details:: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function. Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake. Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).

Versandbedingungen:: Blue Ice