RAD9A antibody [7B11]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX83736
Zusätzliche Namen:: RAD9 checkpoint clamp component A , RAD9
Anwendung:: WB, IHC-P
Konzentration:: 2 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full-length protein expressed in 293T cell transfected with human RAD9A expression vector
Klon:: 7B11
Uniprot:: Q99638
Synonyme:: cell cycle checkpoint control protein RAD9A;DNA repair exonuclease rad9 homolog A;hRAD9;RAD9;RAD9 homolog A
Weitere Details:: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds | endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths | and DNA ligase I (LIG1) on long-patch base excision repair substrates. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.

Versandbedingungen:: Blue Ice