RIC8A antibody [3G3]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX83714
Zusätzliche Namen:: RIC8 guanine nucleotide exchange factor A , RIC8
Anwendung:: WB, IHC-P, IF, ICC
Konzentration:: 0.83 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full length human recombinant protein of human RIC8A (NP_068751) produced in HEK293T cell.
Klon:: 3G3
Uniprot:: Q9NPQ8
Synonyme:: Protein Ric-8A;resistance to inhibitors of cholinesterase 8 homolog A;RIC8;synembryn-A
Weitere Details:: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.