RNF144B antibody [11F4]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX83705
Zusätzliche Namen:: ring finger protein 144B , IBRDC2 , PIR2 , bA528A10.3 , p53RFP
Anwendung:: Flow Cytometry, WB, IF, ICC
Konzentration:: 0.8 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Human recombinant protein fragment corresponding to amino acids 1-256 of human RNF144B (NP_877434) produced in E. coli.
Klon:: 11F4
Uniprot:: Q7Z419
Synonyme:: bA528A10.3;E3 ubiquitin-protein ligase RNF144B;IBR domain containing 2;IBR domain-containing protein 2;IBRDC2;p53-inducible RING finger protein;p53RFP;PIR2;RING finger protein 144B
Weitere Details:: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death | But, it is not an anti-apoptotic protein per se.

Versandbedingungen:: Blue Ice