Shh antibody [10H6]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX83651
Zusätzliche Namen:: sonic hedgehog signaling molecule , HHG1 , HLP3 , HPE3 , MCOPCB5 , SMMCI , ShhNC , TPT , TPTPS
Anwendung:: WB, IF, ICC
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Canine, Human, Rat
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Human recombinant protein fragment corresponding to amino acids 24-197 of human SHH (NP_000184) produced in E.coli.
Klon:: 10H6
Uniprot:: Q15465
Synonyme:: HHG-1;HHG1;HLP3;HPE3;MCOPCB5;shh unprocessed N-terminal signaling and C-terminal autoprocessing domains;ShhNC;SMMCI;sonic hedgehog homolog;sonic hedgehog protein;TPT;TPTPS
Weitere Details:: Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction.

Versandbedingungen:: Blue Ice