GTX80984
COL18A1 antibody, N-term
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX80984
- Zusätzliche Namen:
- collagen type XVIII alpha 1 chain , KNO , KNO1 , KS
- Anwendung:
- Flow Cytometry, WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified; Protein A Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 0.09% Sodium azide.
- Immunogen:
- KLH conjugated synthetic peptide between 237-263 amino acids from the N-terminal region of human COL18A1.
- Uniprot:
- P39060
- Synonyme:
- antiangiogenic agent;collagen alpha-1(XVIII) chain;collagen, type XVIII, alpha 1;endostatin;GLCC;KNO;KNO1;KS;multi-functional protein MFP
- Weitere Details:
- This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
- Versandbedingungen:
- Blue Ice