GTX80914
LDL Receptor antibody, Internal
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX80914
- Zusätzliche Namen:
- low density lipoprotein receptor , FH , FHC , LDLCQ2
- Anwendung:
- Flow Cytometry, WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified; Protein A Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 0.09% Sodium azide.
- Immunogen:
- KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human LDLR.
- Uniprot:
- P01130
- Synonyme:
- FH;FHC;FHCL1;LDL receptor;LDLCQ2;low-density lipoprotein receptor;low-density lipoprotein receptor class A domain-containing protein 3
- Weitere Details:
- The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
- Versandbedingungen:
- Blue Ice