APEX2 antibody, Internal

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX80642
Zusätzliche Namen:: apurinic/apyrimidinic endodeoxyribonuclease 2 , APE2 , APEXL2 , XTH2 , ZGRF2
Anwendung:: Flow Cytometry, WB, IHC-P, IF, ICC
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified; Protein A Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: PBS, 0.09% Sodium azide.
Immunogen:: KLH conjugated synthetic peptide between 143-171 amino acids from the Central region of human APEX2.
Uniprot:: Q9UBZ4
Synonyme:: AP endonuclease 2;AP endonuclease XTH2;APE2;APEX nuclease (apurinic/apyrimidinic endonuclease) 2;APEX nuclease 2;APEX nuclease-like 2;APEXL2;Apurinic-apyrimidinic endonuclease 2;apurinic/apyrimidinic endonuclease-like 2;DNA-(apurinic or apyrimidinic site) endonuclease 2;DNA-(apurinic or apyrimidinic site) lyase 2;XTH2;ZGRF2;zinc finger, GRF-type containing 2
Weitere Details:: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

Versandbedingungen:: Blue Ice