![SHIP1 antibody [SHIP-02]](https://www.genetex.com/upload/website/prouct_img/normal/GTX79893/GTX79893_20191025_AP_001_322_w_23061322_633.webp)
GTX79893
SHIP1 antibody [SHIP-02]
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX79893
- Zusätzliche Namen:
- INPP5D , SHIP , SHIP1 , SIP145 , hp51CN , inositol polyphosphate5phosphatase D , p150Ship , inositol polyphosphate-5-phosphatase D
- Anwendung:
- Flow Cytometry, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- 2-8[o]C Do not freeze.
- Hersteller:
- Genetex
- Host:
- Mouse
- Reaktivitäten:
- Human
- Buffer:
- PBS, 15mM Sodium azide.
- Immunogen:
- Peptide coresponding to a sequence within N-terminal domain of Human SHIP-1.
- Klon:
- SHIP-02
- Uniprot:
- Q92835
- Synonyme:
- hp51CN;Inositol polyphosphate-5-phosphatase of 145 kDa;inositol polyphosphate-5-phosphatase, 145kD;inositol polyphosphate-5-phosphatase, 145kDa;p150Ship;phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1;phosphatidylinositol 4,5-bisphosphate 5-phosphatase;SH2 domain-containing inositol 5'-phosphatase 1;SHIP;SHIP-1;SHIP1;signaling inositol polyphosphate 5 phosphatase SIP-145;signaling inositol polyphosphate phosphatase SHIP II;SIP-145
- Weitere Details:
- This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
- Versandbedingungen:
- Blue Ice