VRK1 antibody [1F6]

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX79470
Zusätzliche Namen:: VRK serine/threonine kinase 1 , PCH1 , PCH1A
Anwendung:: IHC, WB, IHC-P, IF, ICC
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Protein A Purified
Lagerbedingungen:: 2-8[o]C
Hersteller:: Genetex
Host:: Mouse
Reaktivitäten:: Human, Mouse
Buffer:: PBS, 0.1% BSA, 0.05% Sodium azide.
Immunogen:: Recombinant fusion protein GST-VRK1.
Klon:: 1F6
Uniprot:: Q99986
Synonyme:: PCH1;PCH1A;serine/threonine-protein kinase VRK1;vaccinia related kinase 1;vaccinia virus B1R-related kinase 1;Vaccinia-related kinase 1
Weitere Details:: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]