APH1A antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX79306
Zusätzliche Namen:: aph-1 homolog A, gamma-secretase subunit , 6530402N02Rik , APH-1 , APH-1A , CGI-78
Anwendung:: Flow Cytometry, WB, IF, ICC, IP
Konzentration:: 0.69 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Hamster, Human, Mouse
Buffer:: PBS, 0.1% BSA, 0.005% Sodium azide.
Immunogen:: Synthetic peptide, KLH conjugated, corresponding to residues C (245) R R Q E D S R V M V Y S A L R I P P E D (265) of human APH-1aL/CT.
Uniprot:: Q96BI3
Synonyme:: 6530402N02Rik;anterior pharynx defective 1 homolog A;APH-1;APH-1A;aph-1alpha;APH1A gamma secretase subunit;CGI-78;gamma-secretase subunit APH-1A;presenilin-stabilization factor
Weitere Details:: This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]

Versandbedingungen:: Blue Ice