GTX79064
GluR2 (phospho Ser880) antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX79064
- Zusätzliche Namen:
- GLUR2,GLURB,GRIA2,GluA2,GluRK2,HBGR2,glutamate ionotropic receptor AMPA type subunit 2,Glutamate receptor 2,GluR2,Ionotropic Glutamate receptor 2
- Anwendung:
- WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human, Mouse
- Aufreinigung:
- Sequential Chromatography; Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Mouse
- Buffer:
- PBS, 150mM NaCl, 0.5% BSA, 50% glycerol (Please contact us for BSA-free format), 0.02% Sodium azide.
- Immunogen:
- The antiserum was produced against synthesized phosphopeptide derived from human Glutamate receptor 2 (Precursor) around the phosphorylation site of serine 880 (I-E-Sp-V-K) (CYNVYGIESVKI) .
- Uniprot:
- P42262
- Synonyme:
- AMPA-selective glutamate receptor 2;GluA2;gluR-2;gluR-B;GluR-K2;GLUR2;GLURB;glutamate receptor 2;Glutamate receptor ionotropic, AMPA 2;glutamate receptor, ionotropic, AMPA 2;HBGR2;NEDLIB
- Weitere Details:
- Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
- Versandbedingungen:
- Blue Ice