MEK2 (phospho Thr394) antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX79014
Zusätzliche Namen:: CFC4,MAP2K2,MAPKK2,MEK2,MKK2,PRKMK2,mitogenactivated protein kinase kinase 2,mitogen-activated protein kinase kinase 2
Anwendung:: WB, IHC-P
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Sequential Chromatography; Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: PBS, 150mM NaCl, 0.5% BSA, 50% glycerol (Please contact us for BSA-free format), 0.02% Sodium azide.
Immunogen:: The antiserum was produced against synthesized phosphopeptide derived from human MEK2 around the phosphorylation site of threonine 394 (P-G-Tp-P-T).
Uniprot:: P36507
Synonyme:: CFC4;dual specificity mitogen-activated protein kinase kinase 2;ERK activator kinase 2;MAP kinase kinase 2;MAPK/ERK kinase 2;MAPKK2;MEK2;mitogen-activated protein kinase kinase 2, p45;MKK2;PRKMK2
Weitere Details:: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

Versandbedingungen:: Blue Ice