GTX77887
PAR4 antibody, Internal
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX77887
- Zusätzliche Namen:
- pro-apoptotic WT1 regulator , PAR4 , Par-4
- Anwendung:
- WB, IHC-P
- Konzentration:
- 0.5-1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 2% Sucrose, 0.09% Sodium azide.
- Immunogen:
- A synthetic peptide corresponding to an Internal region of Human PAR4.
- Uniprot:
- Q96IZ0
- Synonyme:
- Par-4;PAR4;PRKC apoptosis WT1 regulator protein;PRKC, apoptosis, WT1, regulator;Prostate apoptosis response 4 protein;prostate apoptosis response protein 4;prostate apoptosis response protein PAR-4;prostate apoptosis response-4;transcriptional repressor PAR4;WT1-interacting protein
- Weitere Details:
- This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]
- Versandbedingungen:
- Blue Ice